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Pharmacodynamics is the study of biological measurements that
represent the effects of a drug on the body. Pharmacodynamic
measurements are hugely varied and new pharmacodynamic endpoints are
constantly invented. Some example pharmacodynamic measurements
include
- Protein phosphorylation status of a drug target
- Transcription of genes influenced by the drug
- Downstream physiological responses such as blood pressure
- Assessments of response to stimulus such as a reaction
time or an induced immune response
- Patient reports of symptom severity on continuous or
categorical scales
- Counts of patient events such as seizures
- Durations until critical events like relapse or
hospitalization
The list is potentially endless and encompasses many different types
of data with complex relationships to drug effects and disease
progression.
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