Pharmacodynamics
 
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Pharmacodynamics is the study of biological measurements that represent the effects of a drug on the body.  Pharmacodynamic measurements are hugely varied and new pharmacodynamic endpoints are constantly invented.  Some example pharmacodynamic measurements include

  •   Protein phosphorylation status of a drug target
  •   Transcription of genes influenced by the drug
  •   Downstream physiological responses such as blood pressure
  •   Assessments of response to stimulus such as a reaction time or an induced immune response
  •   Patient reports of symptom severity on continuous or categorical scales
  •   Counts of patient events such as seizures
  •   Durations until critical events like relapse or hospitalization

The list is potentially endless and encompasses many different types of data with complex relationships to drug effects and disease progression.

 

 

 

     

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This site was last updated 21-Jun-2006